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Results We confirmed the presence of the vaccine epitope targets in circulating virus of the vaccinees, to which immune responses could be induced. Our results indicate limited evolution in targeted epitopes despite the induction of additional immunity towards these. However, in some cases de novo immune responses are associated with viral evolution in targeted epitopes. Conclusion We find evidence of escape mutations in HLA-A02 epitopes in HIV-1-positive patients after dendritic cellbased therapeutic vaccination with CD8 epitopes. from AIDS Vaccine 2009 Paris, France. 19–22 October 2009

retrovirology

P18-05. Evidence of escape mutations in HLA-A02 epitopes in HIV-1-positive patients after dendritic cell-based therapeutic vaccination with CD8 epitopes