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Methods We have generated rAd vectors derived from a rare human serotype adenovirus, Ad 28, encoding HIV envelope (rAd28-Env) and evaluated its ability to transduce dendritic cells (DC) in humans and mice. We also have examined the immunogenicity of rAd28-Env in various immunization regimens, such as single intramuscular injection, DNA prime/rAd boost and rAd prime/rAd boost immunizations in mice.

P17-27. Development of recombinant adenovirus 28 vectors for HIV vaccines