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Methods We developed a model for epitope coverage of a target viral population by a T-cell vaccine that expresses coverage as a function of breadth of response (number of epitopes recognized) and the frequency with which vaccineinduced epitope responses are represented in the targeted viral population. This model was used to analyze epitope mapping data from 2 study populations: participants who received the Merck Ad5 HIV vaccine (insert: clade B gag, pol, nef) and participants who received the VRC multigene Ad5 HIV vaccine (insert: clade B gag-pol and clades A, B, C env).

P17-25. A model for coverage of T-cell HIV vaccines: where are we and where do we need to be?