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Background B', B'/C and AE recombinant subtype of HIV-1 occupy the top three of the most prevalent HIV-1 clades in China. Thus, the preliminary object for HIV vaccine development in China is to obtain an efficacious vaccine targeting these clades. In order to assess their potencies to be used as T cell vaccine immunogen, we compared the immunogenicity of DNA vaccines containing tat, rev, integrase (C-half), vif and nef genes derived from the above three subtypes in mice model.

P17-12. Immunogenicity comparison of dna vaccines encompassing HIV-1 tat, rev, integrase (C-half), vif and nef genes derived from different clades