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Background Design of the artificial polyepitope immunogens capable of eliciting high levels of the CD8+ CTL responses to the most of contained epitopes is a promising approach in creation of an efficient vaccine against HIV-1. When designing such immunogens, it is necessary to provide their processing to liberate the epitopes and present them to the immune system. We have demonstrated that DNA vaccine construct encoding poly-CTL-epitope immunogen which contains N-terminal ubiquitin and residues ensuring the proteasome processing of polyepitope construct and transport liberated determinants through the endoplasmic reticulum where they bind to MHC class I molecules is most optimal for stimulating the maximal CD8+ CTL responses. These results inspired us to create PolyCTLDesigner software, intended for designing optimal polyepitope antigens.

P17-02. PolyCTLDesigner: the software for constructing highly efficient polyepitope immunogens. Application to HIV-1