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Background Induction of broadly reactive neutralizing antibodies still remains an elusive goal for HIV vaccine development. Although HIV-1-infected individuals typically develop neutralizing antibodies against Tier 1 isolates, significant breadth in antibody response has been observed only in a few patients. Understanding the mechanism of the induction of broadly neutralizing antibodies in HIV-infected humans may help in designing vaccines capable of eliciting such responses in immunized hosts. SHIV-infected nonhuman primates represent a useful model to understand how such broadly reacting antibodies are induced following infection.

P03-10. Induction of neutralizing antibodies in Rhesus macaques following mucosal challenge with R5 tropic SHIV162P3 isolate