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Background CD8+ T-lymphocytes suppress HIV-1 replication through unknown factors that inhibit HIV-1 transcription initiation. Understanding the regulation of these CD8+ T cell derived factors can provide important insights into how to elicit these factors with a vaccine. For a small subset of human genes, histone deacetylases (HDACs) are epigenetic regulators that condense chromatin to repress transcription. We examined an HDAC inhibitor's ability to modulate the expression of suppressive factors from primary CD8+ T cells from HIV-1+ subjects controlling virus infection.

P16-40. Inhibition of histone deacetylases modulates CD8+ T-lymphocyte mediated virus suppression by HIV-1 viral controllers