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Background A long standing study of low social economic status commercial sex workers in the Majengo cohort has demonstrated variable susceptibility to HIV-1 infection, where some of the highly exposed subjects remain persistently seronegative signifying resistance to HIV-1. There has been intense interest in understanding mechanisms responsible for this phenomenon. Current research has shown that MHC alleles play a significant role in the possible mechanisms of resistance. However, if both HIV infected and resistant individuals have HIV specific T helper responses, then there is a certain uniqueness that protects the latter group from contracting the disease. This study evaluated the protective immunity in the light of specific selective peptide recognition. We analyzed the cellular immune responses by invitro stimulation of PBMC's isolated from the subjects with specific HIV-1 peptide pools.

P16-35. Specific CD4 responses to HIV-1 epitopes in exposed seronegative (ESN) versus infected commercial sex workers