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Background Understanding how elite controllers (EC), patients controlling virus without antiretroviral therapy (ART), differ from those with chronic disease is an area of intense investigation. HIV Gag specific (sp) cytotoxic T lymphocytes (CTL) play a dominant role in this control. Unfortunately, most HIV sp CTL are primed for apoptosis. We hypothesize that EC up-regulate survival factors allowing them to resist apoptosis.

P16-25. HIV specific CTL from elite controllers have a unique survival advantage