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Background Infection with human immunodeficiency virus type 1 (HIV-1) induces dysfunction of CD4+ T cells, and CD4+ Tcell responses do not fully develop in many infected individuals. Previous studies suggested correlations between disease outcome and CD4+ T-cell dysfunction caused by chronic immune activation and abnormal maturation. To understand the mechanism of virally induced T-cell dysfunction, we examined phenotypic changes occurred in the peripheral CD4+ T cells of patients chronically infected with HIV-1.

retrovirology

P16-22. In impact of nadir CD4 counts on skewed distributions of functional subsets in peripheral CD4+ T cells in patients chronically infected with HIV-1