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Background HIV-1-specific T-cell responses are preserved in HIV-1 infected individuals with non-progressing HIV-1 disease. ''Long Term Non Progressors'' (LTNPs) were defined as ART naive individuals infected with HIV-1 for >8 years, maintaining CD4+ T-cell counts >500, and with minimal CD4+ decline over time. We tested the hypothesis that Gag-specific T-cell responses are inversely correlated to disease progression whereas Nef-specific T-cell responses are not.

P16-16. Gag and Nef specific T-cell responses in HIV-1 infected long-term non-progressors in Uganda