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Background The accurate identification of HIV-1-specific T cell responses is important for determining the relationship between immune responses and viral control. Overlapping peptides were synthesized to span gag and nef core 'mosaic' proteins. Mosaic proteins were assembled from fragments of natural sequence using an optimized computational biology method (W. Fischer et al., Nature Medicine, 2007). These proteins resemble natural proteins and were designed to maximize the coverage of potential T cell epitopes. Whilst recent studies have shown that mosaic proteins are highly immunogenic in mice models (W.P. Kong et al., J Virol, 2009), it remains unknown whether mosaics when compared with consensus peptide sets will detect a greater breadth of T cell responses in natural HIV-1 infection.

P16-13. A greater breadth of HIV-1-specific T cell responses detected using mosaic peptides compare to consensus peptides