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Background Autologous neutralizing antibody responses against HIV1 have been shown to emerge a number of months after primary infection. It is not known why neutralizing antibodies against HIV-1 are relatively slow to appear. We use the SIV/rhesus macaque model to characterize the kinetics of autologous neutralizing antibody responses and envelope sequence evolution in 4 rhesus monkeys infected intrarectally with SIVmac251.

P03-07. Autologous neutralizing antibodies that select viral escape variants emerge late after SIV infection of rhesus monkeys