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Background Preservation of IL-17 producing CD4 + T (Th17) cell populations may be beneficial in HIV-1 disease. Despite broad interest in the role of Th17 cells in regulating human immune responses little is known about the manipulation of IL-17 in humans in vivo. IL-2 has been used in conjunction with antiretrovirals to increase CD4+ T-cell counts in HIV-1, and is approved in some European countries for this purpose. We sought to gauge the effects of IL-2 administration on IL-17 production and inflammatory T cell responses among recently HIV infected persons who had achieved virologic suppression on an antiretroviral regimen.

retrovirology

P16-10. IL-2 therapy mediates expansion of Treg cells, maintains IL-17 expressing CD4+ T-cells and selectively suppresses HIV specific T-cell responses