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Results Clades A1, D, and inter-subtype recombinants A1/C, A1/ D occurred at frequencies 44%, 51%, 2.4% and 2.4%, (n = 41), respectively. Infecting gag sequences highly diverged from consensus group-M (median 9.2: interquartile range (IQR) 8.6–10%), and reveled evidence of immunological pressure. Inter-clade divergence was above the 3% threshold in clades A1 (5.3: 4.8–5.8%) and D (6.1: 5.8–6.9%). High avidity Gag (96: 19–267 ng/ml) and Nef-induced IFN-γ responses (74: 12–159 ng/ml) were detected. All gag regions were recognized, highest magnitudes were to p24. Gag was more targeted than Nef (44/50[88%] vs. 32/50[64%]; p = 0.014, Fisher's Exact); and induced higher IFN-γ magnitude (2420, 625–6445 vs. 475: 0–2000 SFU/106 PBMCs; p = 0.0003) and breadth (2: 1–3 vs. 1: 0–1 epitopes; p = 0.0001, MannWhitney), respectively, with no detectable difference between clades. Nef-induced IFN-γ responses targeted the conserved core region, and depicted lower magnitude (0: 0–765 vs. 1090: 275–2310 SFU/106 PBMCs; p = 0.04) and breadth in clade A1 than D (0: 0–1 vs. 1: 1–2 epitopes; p = 0.03), respectively.

P16-03. Persistence of robust cross-reactive group M consensus T-cell responses in a chronic HIV-1 clade A1 and D-infected Ugandan population