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Background In September of 2007, the trial of Merck's MRK-Ad5 AIDS vaccine candidate came suddenly and unexpectedly to a halt. Results suggesting enhanced susceptibility to HIV infection in certain trial participants placed the planned PAVE 100 trial of the Vaccine Research Center's DNA prime/Ad5-vectored boost vaccine strategy into question. At the same time, the Step trial analysis suggested that some vaccines might have benefited from lower viral loads post infection. A year after Step ended, NIAID announced that it was considering a smaller trial of the VRC's strategy, which became HVTN 505 – no longer PAVE 100.

P15-15. Advocates' perspectives on community engagement in the HVTN 505