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Background Live, attenuated SHIV89.6 immunization protects macaques against vaginal challenge with SIVmac239. SIVspecific effector/memory CD8+ T cells, present in the vagina at the time of challenge, mediate this protection and they do not expand dramatically after challenge. Thus, we hypothesized that the persistent, low-level replication of vaccine virus induces regulatory mechanisms which maintain a controlled, inflammatory environment that does not promote viral replication.

P01-02. Anti-inflammatory and regulatory mechanisms provide the context for an effective CD8+ T cell response in live-attenuated immunized animals