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Results DNA delivery using EP led to greatly enhanced expression of SIV antigens and increased cellular responses (up 3% of total T cells) that were broad, long-lasting (up to 45 weeks post vaccination) and included cells of multifunctional phenotype. SIV-specific cellular responses were found both in blood, BAL and rectal mucosa. Interestingly, compared to blood, the responses in BAL were consistently higher (up to 2 log) and included a higher frequency of polyfunctional cells. The cellular responses were characterized as predominantly EM CD4+ and CD8+ T cells in BAL and as both CM and EM T cells in blood. EP DNA delivery elicited both systemic and mucosal humoral immune responses, including the induction of Gag-specific IgA. Upon high dose SIVmac251 challenge, the vaccinated animals showed statistically significant lower VL peak in acute (1 log10) and in chronic viremia (1.7 log10).

retrovirology

P14-08. Intramuscular DNA delivery by electroporation leads to greatly enhanced systemic and mucosal immune responses and control of SIVmac251 challenge