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Background Two of the existing broadly neutralizing antibodies (NAbs) to HIV-1 Env, 2F5 and 4E10, recognize conserved continuous epitopes in the gp41 membrane-proximal external region. Re-elicitation of NAbs to the 2F5 epitope by immunization with peptides or chimeric proteins has so far proven difficult. To improve the efficiency of eliciting 2F5 epitope-directed NAbs, computationally designed scaffold proteins were used for more optimal presentation of the crystallographically defined 2F5 epitope (2F5E) to B cells. Here, we characterize 2F5E-specific B cell subsets and serum responses elicited by homologous and heterologous scaffold immunizations, with the overall goal to understand the rules of immuno-focusing in this novel system.

P12-12. Analysis of antibody and B cell responses following inoculation with computationally designed HIV-1 2F5 epitope scaffold proteins