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Background Two broadly neutralizing human monoclonal antibodies (mAbs), 4E10 and 2F5, have antigen binding paratopes that simultaneously bind to peptide sequences on gp41 and also to various lipids, such as phospholipids, galactosyl ceramide (GalCer) or cholesterol (Chol) (BBA 2009;1788:660-665). We aimed to create a method to induce murine polyclonal and mAbs by immunization in which the induced antibodies bind simultaneously both to gp41 sequences and to individual lipids in the adjacent lipid bilayer.

P12-08. Membrane-specific antibodies that simultaneously bind to gp41 of HIV-1 and membrane lipid epitopes are induced by immunization with liposomes