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Background The search for novel immunogens capable of eliciting neutralizing antibodies (NAbs) against HIV-1 is complicated by its high mutation rate which modifies envelope glycoproteins (Env) during the course of HIV-1 infection and drives NAb escape. However Env from transmission strains due to absence of NAb selection pressure could be antigenically distinct from late stage Env and hence profiling them would help identify novel vaccine immunogens capable of eliciting NAbs.

retrovirology

P12-01. Construction and characterization of recombinant envelope glycoproteins derived from HIV-1 pre-seroconversion strains as potential vaccine immunogens