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Background Infection of rhesus macaques with live-attenuated SIV strains provides the best known protection against challenge with pathogenic SIV. A cohort of 10 Indian rhesus macaques infected by Rev-independent live-attenuated SIV was monitored for up to 10 years. After the initial acute phase, virus replication was controlled and plasma viral loads were persistently below the threshold of the assay. None of the animals showed any signs of immune dysfunction.

P11-19. Altered mucosal distribution of SIV-specific T cells in Rhesus macaques infected with the live-attenuated Rev-independent SIV