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Background The induction of a protective immune response against HIV remains elusive. In the majority of new HIV infections, virus traverses the mucosal barrier. A rapid and dramatic depletion of CD4+ T cells occurs in the gastrointestinal tract accompanied by active HIV replication. The Rhesus macaque/SIV model recapitulates mucosal transmission and pathogenesis, thus offering a means for a much-needed comprehensive surveillance of the innate and adaptive mucosal immune response during preand post-vaccination, and challenge. In preparation for preclinical studies we used mucosal tissues isolated from SIVinfected and uninfected Rhesus macaques to develop an integrated methodology to characterize by confocal immunofluorescence microscopy the gut associated lymphoid tissue (GALT), virus-specific immune responses and tissue architecture.

P11-02. In situ analysis by confocal microscopy of the cellular components of mucosal tissues within the framework of preclinical vaccine studies