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Background Defensins are natural peptides with potent anti-HIV activity. In humans two subfamilies exist, αand β-defensins. α-Defensins 1–3 are mainly secreted by neutrophils, although other leukocytes also produce them. Besides their direct antimicrobial effect, α-defensins 1–3 also exert immunomodulory activities, chemoattracting leukocytes and inducing cytokines and chemokines production. We previously demonstrated that immature monocytederived dendritic cells (MDDC produce and secrete αdefensins 1–3 and that these defensins are able to modulate de maturation and differentiation of dendritic cells.

retrovirology

P10-13. Increased production of alpha-defensins 1–3 by dendritic cells in HIV-infected individuals is associated with a slower disease progression rate