English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Results MyD88-/mice immunized with 3 × 108 vp of each respective rAd vector generated significantly diminished tetramer-positive CD8+T-cell responses as compared with WT mice. By day 28 post-immunization, rAd5-Gag produced mean tetramer-positive responses of 3.5% in MyD88-/mice as compared with 12.6% in WT mice (p = .0004). Similarly, tetramer-positive responses elicited by rAd5HVR48-Gag (4.4% vs 9.0%), rAd26-Gag (0.3% vs 6.3%) and rAd35-Gag (3.7% vs 6.6%) were also significantly diminished in MyD88-/mice as compared with WT mice. These results were confirmed by functional IFNgamma ELISPOT assays. However, dependence on MyD88 was overcome when rAd vectors were given at higher doses. In contrast, TRIF-/mice immunized with 3 × 108 vp of rAd vectors mounted comparable or higher tetramer-positive responses as compared with WT mice. TLR9-/mice immunized with these rAd vectors displayed no difference in antigen-specific CD8+ T-cell responses when compared to WT mice.

P10-06. Adaptive immune responses elicited by recombinant adenovirus vectors exhibit partial MyD88 dependence