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Methods We induced escape variants by exposing a neutralizationsensitive primary R5 isolate, HIV-1MTA to increasing concentrations of KD-247 in PM1/CCR5 cells. The virus was initially exposed 1 or 0.05 μg/ml of KD-247 and was serially passaged up to 1000 μg/ml. We determined the changes in the amino acid (aa) sequences of gp120encoding region at each passage and monitored neutralization sensitivity of the passaged virus by WST-8 assay. To compare replication fitness of the escape mutants a competition assay was performed in the presence or absence of KD-247.

retrovirology

P09-16. A primary R5 isolate undergoes different escape pathway during in vitro selection with low or high concentration of an anti-V3 monoclonal antibody