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Background Previously we identified patient H19659 who early in his progressive course of infection had HIV-1 variants that were relatively sensitive to neutralization by b12, but who later in infection developed viruses that were highly resistant to b12 neutralization. This increased b12 resistance coincided with an increase in viral replicative capacity. Here we investigated which changes in Env accounted for the differences in replication rate and sensitivity to b12 neutralization between HIV-1 variants that were isolated early and late in the course of infection from this patient and whether immune pressure in vivo was involved in selection of viruses.

P09-14. Emergence of b12 resistant rapidly replication HIV-1 variants during natural infection in the absence of humoral or cellular immune pressure