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Background Control of HIV replication is determined by a complex interaction of viral genetic, host genetic and immune factors, the understanding of which is crucial to developing an effective vaccine. In some studies, HIV Gag immune responses correlate with low viral loads and it is hypothesised that some HLA alleles select for escape mutations in conserved Gag epitopes, resulting in a fitness cost. We are investigating the impact of HLA-driven variation in Gag on fitness and disease progression in a population of 451 HIV-1 subtype C infected individuals.

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression