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Background Many calls have been made for vaccines that induce both CTL and Nab but why this would be substantially more effective, nor the path to achieve this, are unclear. HIV-1 Env is the only protein subject to both NAb and CTL pressure. We hypothesized that serially escaping both Envspecific CTL and NAb responses could have implications for both viral fitness and the reversion of multiple mutations upon transmission to naive hosts.

P09-07. Balancing reversion of CTL and neutralizing antibody escape mutations within HIV-1 Env upon transmission