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Results The data show that gp120 and ICAM-1 on the bilayers can induce the formation of a synaptic structure by noninfected CD4+ T cells with some characteristics of an immunological synapse (IS). There is a transient stop signal and the interface contains a central supramolecular activation cluster (cSMAC) of gp120-CD4 interactions surrounded by a peripheral supramolecular activation cluster (pSMAC) of ICAM-1-LFA-1 interactions. As with the IS, the cSMAC is also formed from microclusters that are enriched in active Src family kinases. However, while Src kinase signaling is suppressed in the cSMAC of the IS, the Src family kinases and other TCR signaling components remain active for a prolonged period in the cSMAC of the VS. Notably, the gp120-enriched cSMAC region of the VS is depleted of f-actin.

P07-03. HIV gp120 interaction with CD4+ T cells induces local intracellular signaling and creates an F-actin depleted zone in the virological synapse