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Background To date, little is known about the mechanisms of the sexual transmission of HIV and how the virus interacts with the female genital epithelium to gain access to underlying target cells. We illustrate that HIV is able to penetrate both intact columnar and squamous epithelium in explants and the living rhesus macaque. Through a series of approaches we were able to determine the mechanism of HIV entry into these tissues.

OA011-02. Defining the mechanisms of HIV entry and interactions with the female genital tract