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Background A vaccine capable of stimulating protective anti-viral antibody responses is needed to curtail the global Acquired Immunodeficiency Syndrome (AIDS) epidemic caused by HIV-1. Although rarely elicited during the course of natural infection or upon conventional vaccination, the membrane proximal ectodomain region (MPER) of the HIV-1 gp41 envelope protein subunit is the target of three such human broadly neutralizing antibodies (BNAbs): 4E10, 2F5 and Z13e1. How these BNAbs bind to their lipidembedded epitopes and mediate anti-viral activity are unclear, but such information might offer important insight into a world-wide health imperative.

S021-05 OA. Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface