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Background The success of a T cell-based vaccine relies not only on the identification of protective epitopes but also on the capacity of vaccinated tissues to produce and present these epitopes to immune cells. Defining predictable events leading to efficient epitope presentation is critical to immunogen design. Epitopes are short protein fragments escaping degradation, but factors controlling the efficiency of epitope production are unknown. We previously identified portable flanking sequences altering epitope production and antigenicity. In order to define motifs driving efficient epitope production, we analyzed the degradation of long HIV peptides into shorter fragments as well as the capacity of antigenic peptides to sustain intracellular degradation.

retrovirology

SO4-05 OA. The intracellular production of HIV antigenic peptides is guided by predictable motifs and can be altered: implications for immunogen design