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Background We have previously reported dramatic increases in immune responses induced by DNA vaccines delivered by electroporation (EP), resulting in improved control of viral replication following a SIVmac251 challenge. We compared the immunogenicity of DNA+EP to the Ad5 vaccine, the most potent recombinant viral vector for the generation of CTL responses in macaques and humans. Futhermore, we were interested in examining the effect of prime/boost strategies using these two platforms on the magnitude and phenotype of the immune response.

retrovirology

OA05-02. Analysis of DNA compared to Ad5 vaccination, as single and mixed modalities, demonstrates robust induction of cellular immune responses in macaques