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Methods HIV-1(+) subjects on ART (n = 17) were enrolled in a phase I therapeutic vaccine trial where they received 2 doses of autologous dendritic cells loaded with HIV-1 peptides. Peripheral blood mononuclear cells (PBMC) obtained from the subjects preand post-vaccine, and from normal controls (NC) were stained with antibodies specific for Treg (CD4+CD25hiFOXP3+), CD45RO, GITR, and CTLA4 and assayed by flow cytometry. PBMC pre and post-vaccine from 7 subjects were also evaluated for polyfunctionality using a flow cytometry-based, CD8+ T cell intracellular cytokine staining assay for 5 immune mediators after stimulation with Gag peptide, staphylococcal enterotoxin B (SEB) and medium alone. Treg were depleted in one set, and total vaccine response (post-vaccine pre-vaccine) was compared in the Treg(+) and Tregdepleted (Treg-) sets.

retrovirology

OA031-03. Increased regulatory T cell frequency and HIV-1 specific suppression after therapeutic vaccination of HIV-infected patients on antiretroviral therapy