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Background Mother-to-child transmission (MTCT) of HIV-1 provides a model for studying the role of passively acquired antibodies in preventing infection. We previously hypothesized that broadly neutralizing heterologous antibodies (NAbs) would protect babies against intrapartum (IP) transmission. We measured NAb titers against primary isolates of various clades in sera from pregnant Thai women, and identified an association between higher titers of Nabs against a CRF01_AE primary isolate, MBA, and lower rates of IP transmission. Here, we extended our previous study using three CRF01_AE strains in a different Thai population, to confirm the association previously observed. We also investigated the molecular characteristics of the MBA envelope glycoprotein (Env) that might explain this association.

Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission in Thailand