English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

HTLV-1 Tax can induce senescence by up-regulating the levels of cyclin-dependent kinase inhibitors p21 CIP1/WAF1  and p27 KIP1 . Tax increases p27 KIP1  protein stability by activating the anaphase promoting complex/cyclosome (APC/C) precociously, causing degradation of Skp2 and inactivation of SCF Skp2 , the E3 ligase that targets p27 KIP1 . The rate of p21 CIP1/WAF1  protein turnover, however, is unaffected by Tax. Rather, the mRNA of p21 CIP1/WAF1  is greatly up-regulated. Here we show that Tax increases p21 mRNA expression by transcriptional activation and mRNA stabilization. Transcriptional activation of p21 CIP1/WAF1  by Tax occurs in a p53-independent manner and requires two tumor growth factor-β-inducible Sp1 binding sites in the -84 to -60 region of the p21 CIP1/WAF1  promoter. Tax binds Sp1 directly, and the CBP/p300-binding activity of Tax is required for p21 CIP1/WAF1  trans-activation. Tax also increases the stability of p21 CIP1/WAF1  transcript. Several Tax mutants trans-activated the p21 promoter, but were attenuated in stabilizing p21 CIP1/WAF1  mRNA, and were less proficient in increasing p21 CIP1/WAF1  expression. The possible involvement of Tax-mediated APC/C activation in p21 CIP1/WAF1  mRNA stabilization is discussed.

Induction of p21CIP1/WAF1expression by human T-lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization