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Background Interferon gamma is a licensed product for treating certain immune deficiency diseases, but its use in people with HIV is experimental. IFNis normally made by CD4 Tcells – the cells which are depleted in people with AIDS and it has antineoplastic effects and antiviral activity mediated by immunomodulatory effects. At a cellular level these include macrophage activation, stimulation of antigen presentation through class I and class II major histocompatibility complex molecules, regulation of leukocyte-endothelium interaction, and effects on cell proliferation and apoptosis. It is therefore theorized that giving HIV-positive people co-infected with TB supplementary injections of interferon gamma may help boost their immune response.

retrovirology

Immune-based therapy using gamma interferon ingaron in the treatment of HIV/AIDS patients with active pulmonary tuberculosis (PTB) not previously highly active antiretroviral therapy (HAART)