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Results The optimized CV-N expression cassette was stably integrated in single copy into the lactobacillus bacterial chromosome, and resolved from extraneous plasmid DNA and antibiotic resistance determinants. The L. jenseniiexpressed CV-N dramatically decreased CCR5-trophic HIVBaL infectivity in vitro, with an IC50 of 0.3 nM. Histological examination of CD1 mice, which were intra-vaginally inoculated with L. jensenii expressing CV-N, revealed that L. jensenii was associated with keratinized epithelium present during estrus or free in the vaginal lumen and secreted full-length CV-N in vivo.

Development of Vaginal Lactobacilli for Mucosal Delivery of a Topical Microbicide, Cyanovirin-N (CV-N)