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Most of the HIV-1 vaccines under development contain multiple viral genes or proteins. As a result, many vaccinerecipients react positive in licensed HIV-1 detection assays. This will have negative impact on future efficacy trials of prophylactic HIV vaccines that require early detection of intercurrent HIV infections. It will also exclude all vaccinees from blood/plasma donations, and may contribute to other social harms. Therefore, it is important to design new strategies for vaccine trial participants that will clearly discriminate between vaccine-induced antibodies and true HIV-1 infection. We identified new HIV-1 epitopes that: 1) Do not contain important neutralizing or CTL epitopes, and can be omitted from future HIV vaccine candidates, 2) Recognized by antibodies from early HIV infected individuals, 3) Highly conserved among HIV-1 clades and subtypes. Using Phage Display libraries constructed from whole HIV-1 genome, combined with panning over antibodies from early seroconvertors, we identified new immunodominant epitopes, in the gp41 intracytoplasmic tail and in p6, which conform to the above criteria.

retrovirology

HIV-1 Infections During Vaccine Trials: Identifying New Epitopes For Differential Diagnosis Of HIV-1 Infections In The Face Of Vaccine -Induced Antibodies