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Vaccines based on plasmid DNA (pDNA) or recombinant vesicular stomatitis virus (rVSV) vectors elicit HIV-1-specific cellular and humoral immune responses in small animal models. However, hurdles remain with each of these vaccine modalities before they can be considered for widespread clinical use. For pDNA vaccines, early clinical studies indicate that additional measures are needed to improve immunogenicity. For rVSV-based vaccines, issues related to the potential neurovirulence of the prototype vector represent a safety concern.

Development of pDNA and Recombinant VSV Vectored Vaccines for Immunization Against HIV