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Results Matched TW data (baseline+6 months) were available for a total of 76 patients. Mean (SD,median) TW were 23.46 (±18.9,16.32) at baseline, 24.85 (±23.89,16.38) at 6 months. Mean (SD,median) log10m TW were 2.89 (±0.72,2.79) at baseline, 2.91 (±0.74,2.80) at 6 months. The estimated SD of log10m TW after adjustment for the baseline measurement was 0.26. With 30 participants/group, we have 90% power to detect a difference of ±0.21. This corresponds to a ratio of 0.81 or 1.23, so we could detect a decrease in time of 19% or an increase of 23%. With power 80% we could detect a difference of -15% or +18%.

Change in timed walk as primary outcome measure of treatment response in HAMLET-P: HAM/TSP MuLticentre Efficacy trial-Prednisolone