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Background Macrophages play crucial roles in HIV/AIDS pathogenesis as they are important targets for HIV-1 replication and contribute to viral spread and viral reservoir formation. We have previously reported that p21 inhibits HIV-1, HIV-2 and SIV replication in macrophages by a major block at the level of reverse transcription [1]. This study aimed at understanding the molecular mechanisms involved in p21-mediated restriction.

RNR2 repression by p21 restricts reverse transcription of HIV-1 and related-lentiviruses in macrophages