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Background In asthmatic lungs, elevated levels of thymic stromal lymphopoetin (TSLP) are linked to eosinophilic inflammation and disease severity [1]. TSLP is involved in initiating a TH2 inflammatory response, through activation of T cells, and recently, CD34+ hemopoietic progenitor cells [2,3]. However, the biological effects of epithelial-derived TSLP on human peripheral blood (PB) CD34+ progenitor eosinophil-basophil (Eo/B) lineage commitment have not been described. The aim of the current study is to examine the effects of primary bronchial epithelial cell-derived TSLP on CD34+ hemopoietic progenitor differentiation.

allergy, asthma and clinical immunology/allergy, asthma, and clinical immunology

The effects of poly I:C stimulation of primary bronchial epithelial cells and TSLP secretion on CD34+ progenitor cell eosinophil and basophil differentiation