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Methods Seventy-one singleton infants born at term were classified by birth weight as AGA (10th-90th percentile; n=42) and as LGA (>90th percentile; n=29). Post-natal follow-up until age 1 year was performed with clinical assessments at 3, 6, and 12 months. Assessments included measurement of infants’ weight, length, ponderal index, BMI, as well as head, chest, and abdominal circumference. A subgroup of 38 infants (17 AGA and 21 LGA) was selected for genome-wide DNA methylation analysis. Umbilical cord was collected at birth, and methylation profile on umbilical tissue was analysed using the Illumina Infinium 450K methylation array.

LGA infants display early catch down growth in length and weight without epigenetic changes