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Methods In a prospective, randomized, double blind, active-comparator-controlled, parallel group pilot study, 30 male subjects, age 27.0 ± 4.6 years, with BMI of 24.75 ± 1.99 kg/m and a body surface area (BSA) of 1.953 ± 00.75 m, were randomly assigned to ingest 3 grams of creatine monohydrate (CM) in combination with isomaltulose (ISO) or dextrose (DEX) in 1 of 3 concentrations (5 gm liquid, 17 gm capsules or 50 gm liquid). Rate of absorption (tMax) and overall absorption (from BSA adjusted AUC0-8h and CMax) of CM was determined via changes in serum creatine over an 8-hour test period. Blood was collected at baseline and 0.5, 1, 2.5, 4 and 8 hours post ingestion with efficacy endpoints including CMax, tMax, AUC0-8h and lElim derived from normalized concentration vs. time curves for serum creatine (AUC by trapezoidal integration). Serum creatine levels were normalized by BSA using the Mosteller formula. For PK parameters, paired Student t test (or Wilcoxon if nonnormally distributed) was used and for categorical variables, Fisher Exact test (or Chi-Square if necessary) was used. Statistics were calculated by R v2.14.0 (www.r-project.org).

journal of the international society of sports nutrition

A double blind clinical trial evaluating the relative pharmacokinetics and bioavailability of oral creatine monohydrate when combined with either isomaltulose or dextrose in healthy adult males