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Background Alpha-glycerylphosphorylcholine (Alpha-GPC) and caffeine supplementation have been shown to improve mental and physical performance. Alpha-GPC administration increases the release of the neurotransmitter acetylcholine and facilitates learning and memory. In athletes, Alpha-GPC supplementation prevents exerciseinduced reductions in choline levels, increases endurance performance and growth hormone secretion. Caffeine has been shown to increase mental focus, acuity and athletic performance, however, contributes to a nervous or anxious feeling. The purpose of this study was to measure the acute effects of Alpha-GPC supplementation in comparison to caffeine or placebo on mood, cognitive function, and physiological performance.

The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility