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Background Caffeine has been associated with enhancing the ability to perform mental tasks and elevate feelings of energy, however, a single dose of caffeine typically induces only 90-120 minutes of increased alertness and is often associated with an acute “crash” state following its metabolism. The nature of formulation can directly influence the rate and extent of absorption following oral administration. Time-release caffeine supplements have been developed to prolong the effects of caffeine. The purpose of this study was to compare the plasma caffeine pharmacokinetics following ingestion of a time-release caffeine capsule (TR-CAF) to an equivalent dose of a regular caffeine capsule (CAF) and a placebo (PL) over an 8-hour period.

Pharmacokinetics of caffeine administered in a time-release versus regular tablet form