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Results Females constituted 84% of the cohort with a median age at diagnosis of 13.1 years. The mean LS BMD zscores decreased with time. Initially, 9% of patients had a low BMD, this proportion increased to 19% by 3 years after diagnosis. Overall, the BMD category decreased in 35% of patients from 1 to 3rd DEXA study. LS BMD followed a general deteriorating trajectory of -0.25 z-score/year from diagnosis. Body mass index (BMI) z-score and cumulative steroid dose were the best predictors of BMD trajectories over time. Conclusions The LS BMD of pSLE patients decreased at a rate of 0.25 z-score/year. BMI z-score and cumulative doses of steroids modified the trajectories of LS BMD. These factors are potentially modifiable targets that can improve individual patient’s BMD trajectory.

Identification of predictors of bone mineral density trajectories in pediatric Systemic Lupus Erythematosus patients