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Methods We launched a non-interventional study with analysis of clinical, biological and pharmacokinetic information. Full-PK profiles of MPA were modelled using an iterative two-stage approach (1). The clinical status was defined by the SLEDAI, the SLE being considered active for a score ≥6. Relationships between MPA through concentrations (C0), AUC (Area Under Curve) or AUC/ dose values, and the disease’s activity were studied using logistic regression analysis.

Is there any relationship between the exposure to mycophenolic acid and the clinical status in children with lupus?